![]() ![]() With a high-salt diet, the one typically consumed today, the rigorous relationship of aldosterone to sodium balance begins to break down with the result that more aldosterone is produced than is needed, driving the distal nephron, the guardian of overall sodium homeostasis, to a state of overactivity. The regulation of aldosterone secretion is driven by the need to defend against sodium deficiency or an elevated potassium. Customer Service and Ordering InformationĪldosterone signals the distal nephron to reabsorb sodium and secrete potassium.Stroke: Vascular and Interventional Neurology.Journal of the American Heart Association (JAHA).Circ: Cardiovascular Quality & Outcomes. ![]() Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB).
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